Endothelial cells instigate sepsis
نویسندگان
چکیده
منابع مشابه
Endothelial cells instigate sepsis
Lipids heading toward lysosomes that carry a mutated ion channel are spared from destruction, according to Meidel et al. (page 1477). The accumulating undigested fat eventually dooms the cell. Cells get rid of excess fat, which comes from worn-out organelles or engulfed pathogens by, for instance, shuttling them in endosomes to degradative lysosomes. The two organelles are thought to fuse when ...
متن کاملMesenchymal Stem Cells Differentiate to Endothelial Cells Using Recombinant Vascular Endothelial Growth Factor –A
Background: Vascular endothelial growth factor-A (VEGF-A), an endothelial cell-specific mitogen produced by various cell types, plays important roles in cell differentiation and proliferation. In this study we investigated the effect of recombinant VEGF-A on differentiation of mesenchymal stem cells (MSCs) to endothelial cells (ECs). Methods: VEGF-A was expressed in E. coli BL21 (DE3) and BL21...
متن کاملSepsis and endothelial permeability.
Sepsis, derived from the Greek verb sepo (meaning “I rot”), has been recognized for millennia and refers to the disseminated inflammatory response elicited by microbial infections. Despite its ancient etymology, sepsis remains a current challenge: it is increasing in frequency, expensive to treat, and lethal, with an associated rate of death as high as 70%.1 Despite intensive research over deca...
متن کاملCDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells
Neuroblastoma is the most common solid extra cranial tumor in infants. Improving the clinical outcome of children with aggressive tumors undergoing one of the multiple treatment options has been a major concern. Differentiating neuroblastoma cells holds promise in inducing tumor growth arrest and treating minimal residual disease. In this study, we investigated the effect of partial PPARγ agoni...
متن کاملRadiation-induced expression of platelet endothelial cell adhesion molecule-1 in cerebral endothelial cells
Background: Radiation-induced molecular changes on the endothelial surface of brain arteriovenous malformations (AVM) may be used as markers for specific vascular targeting agents. In this study, we examined the level of expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) on brain endothelial cell surface after radiation treatment, with the aim of targeting the radiation-induc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2008
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2056iti5